| Date | Team | Status |
|---|---|---|
| 11/25/09 | Buffalo Bills | Placed on IR G Seth McKinney left knee |
| 11/25/09 | Houston Texans | Placed on IR S Eugene Wilson toes |
| 11/25/09 | Kansas City Chiefs | Placed on IR CB Maurice Leggett shoulder |
| 11/25/09 | Philadelphia Eagles | Practice squad addition G Greg Isdaner |
| 11/25/09 | Buffalo Bills | Activated from the Practice Squad C Christian Gaddis |
| 11/25/09 | Buffalo Bills | Practice squad addition DT Lonnie Harvey |
| 11/25/09 | Buffalo Bills | Practice squad addition T Jason Watkins |
| 11/25/09 | Washington Redskins | Activated from the Practice Squad QB Richard Bartel |
| 11/25/09 | Washington Redskins | Practice squad addition RB Jonathan Evans |
| 11/25/09 | Jacksonville Jaguars | Signed CB Michael Coe |
| 11/25/09 | Jacksonville Jaguars | Practice squad addition RB Allen Patrick |
| 11/25/09 | Houston Texans | Signed S Brian Russell |
| 11/25/09 | St. Louis Rams | Activated from the Practice Squad TE Eric Butler |
| 11/25/09 | Miami Dolphins | Activated from the Practice Squad T Andrew Hartline |
| 11/25/09 | Cleveland Browns | Acquired from waivers LB Matt Roth |
| 11/25/09 | Green Bay Packers | Placed on IR CB Al Harris left knee |
| 11/24/09 | New York Giants | Practice squad addition S Anthony Scirrotto |
| 11/24/09 | Oakland Raiders | Cut CB John Bowie |
| 11/24/09 | Detroit Lions | Practice squad addition CB Paul Pratt |
| 11/24/09 | Oakland Raiders | Taken off IR CB John Bowie knee |
| 11/24/09 | Philadelphia Eagles | Signed T Winston Justice Four-year extension (through 2013) |
| 11/24/09 | San Diego Chargers | Placed on IR T Jeromey Clary ankle |
| 11/24/09 | Tampa Bay Buccaneers | Placed on IR QB Byron Leftwich right elbow |
| 11/24/09 | Buffalo Bills | Placed on IR G Eric Wood broken left leg |
| 11/24/09 | St. Louis Rams | Placed on IR DE C.J. Ah You knee |
| 11/24/09 | Baltimore Ravens | Placed on IR RB Matt Lawrence knee |
| 11/24/09 | Baltimore Ravens | Placed on IR CB Fabian Washington torn left ACL |
| 11/24/09 | Carolina Panthers | Placed on IR LB Landon Johnson MCL |
| 11/24/09 | Tampa Bay Buccaneers | Activated from the Practice Squad QB Rudy Carpenter |
| 11/24/09 | Tampa Bay Buccaneers | Activated from the Practice Squad WR Terrence Nunn |
| 11/24/09 | Tampa Bay Buccaneers | Cut CB Mike Mickens |
| 11/24/09 | Buffalo Bills | Signed G Kendall Simmons |
| 11/24/09 | Arizona Cardinals | Practice squad deletion DT Antoine Holmes |
| 11/24/09 | Arizona Cardinals | Practice squad deletion TE Jed Collins |
| 11/24/09 | Indianapolis Colts | Cut RB Mike Hart |
| 11/24/09 | Miami Dolphins | Cut S Nate Ness |
| 11/24/09 | Philadelphia Eagles | Activated from the Practice Squad CB Geoffrey Pope |
| 11/24/09 | Philadelphia Eagles | Cut CB Jack Ikegwuonu |
| 11/24/09 | Arizona Cardinals | Signed LB Monty Beisel One-year contract |
| 11/24/09 | Arizona Cardinals | Cut TE Dominique Byrd |
| 11/24/09 | Chicago Bears | Practice squad addition TE Kevin Brock |
| 11/24/09 | Cincinnati Bengals | Signed DT Orien Harris |
| 11/24/09 | Cincinnati Bengals | Cut T Scott Kooistra |
| 11/24/09 | Cincinnati Bengals | Practice squad addition CB Antonio Smith |
| 11/24/09 | Jacksonville Jaguars | Cut LB Adam Seward |
| 11/24/09 | Jacksonville Jaguars | Practice squad addition LB Lamar Myles |
| 11/24/09 | Jacksonville Jaguars | Practice squad addition DE James Wyche |
| 11/24/09 | Pittsburgh Steelers | Signed LB Rocky Boiman One-year contract |
| 11/24/09 | Pittsburgh Steelers | Signed CB Corey Ivy One-year contract |
| 11/24/09 | Pittsburgh Steelers | Practice squad addition T Jonathan Palmer |
