| Date | Team | Status |
|---|---|---|
| 11/08/09 | Kansas City Chiefs | Cut WR Bobby Engram |
| 11/08/09 | Detroit Lions | Cut WR John Standeford |
| 11/08/09 | Detroit Lions | Activated from the Practice Squad DT Joe Cohen |
| 11/08/09 | Miami Dolphins | Cut LB William Kershaw |
| 11/08/09 | Miami Dolphins | Activated from the Practice Squad LB J.D. Folsom |
| 11/08/09 | New England Patriots | Activated from the Practice Squad CB Kyle Arrington |
| 11/08/09 | Kansas City Chiefs | Activated from the physically unable to perform list RB Kolby Smith |
| 11/08/09 | Tennessee Titans | Cut WR Chris Davis |
| 11/08/09 | Tennessee Titans | Activated from the Practice Squad C Fernando Velasco |
| 11/07/09 | Jacksonville Jaguars | Placed on IR CB Scott Starks hamstring |
| 11/07/09 | Indianapolis Colts | Signed TE Tom Santi |
| 11/07/09 | Jacksonville Jaguars | Acquired from waivers S Anthony Smith |
| 11/07/09 | Green Bay Packers | Activated from the Practice Squad WR Biren Ealy |
| 11/07/09 | New Orleans Saints | Activated from the Practice Squad DT DeMario Pressley |
| 11/07/09 | Green Bay Packers | Placed on IR C Jason Spitz back |
| 11/07/09 | New Orleans Saints | Placed on IR DT Kendrick Clancy knee |
| 11/07/09 | Denver Broncos | Cut CB Jack Williams |
| 11/06/09 | Washington Redskins | Signed P Sam Paulescu |
| 11/06/09 | Indianapolis Colts | Placed on IR S Bob Sanders biceps |
| 11/06/09 | Indianapolis Colts | Signed DE Josh Thomas |
| 11/06/09 | New England Patriots | Cut G Kendall Simmons |
| 11/06/09 | Washington Redskins | Cut RB Quinton Ganther |
| 11/06/09 | Indianapolis Colts | Placed on IR CB Marlin Jackson left knee |
| 11/06/09 | Denver Broncos | Signed/unrestricted free agent CB Ty Law |
| 11/05/09 | Atlanta Falcons | Placed on IR C Mike Schneck ribs |
| 11/05/09 | Atlanta Falcons | Signed C Bryan Pittman |
| 11/04/09 | Seattle Seahawks | Placed on IR S C.J. Wallace hamstring |
| 11/04/09 | Kansas City Chiefs | Signed CB Travis Daniels |
| 11/04/09 | Arizona Cardinals | Practice squad addition TE Jed Collins |
| 11/04/09 | San Francisco 49ers | Practice squad addition T Kirk Barton |
| 11/04/09 | Indianapolis Colts | Activated from the Practice Squad LB Cody Glenn |
| 11/04/09 | Indianapolis Colts | Practice squad addition WR Sam Giguere |
| 11/04/09 | Atlanta Falcons | Signed S Charlie Peprah |
| 11/04/09 | Houston Texans | Activated from the Practice Squad DE Jesse Nading |
| 11/04/09 | Houston Texans | Practice squad addition TE Dezmond Sherrod |
| 11/04/09 | New Orleans Saints | Practice squad addition CB Mark Parson |
| 11/04/09 | Oakland Raiders | Practice squad addition WR Shaun Bodiford |
| 11/04/09 | San Diego Chargers | Practice squad addition LB Jeremy Leman |
| 11/04/09 | Houston Texans | Practice squad addition LB Marcus Freeman |
| 11/04/09 | Kansas City Chiefs | Placed on IR S Jarrad Page calf |
| 11/04/09 | Indianapolis Colts | Placed on IR LB Tyjuan Hagler biceps |
| 11/04/09 | Atlanta Falcons | Placed on IR S Jamaal Fudge undisclosed |
| 11/04/09 | Houston Texans | Placed on IR TE Owen Daniels torn right ACL |
| 11/03/09 | Cincinnati Bengals | Cut T Scott Kooistra |
| 11/03/09 | Arizona Cardinals | Practice squad addition DT Antoine Holmes |
| 11/03/09 | Tampa Bay Buccaneers | Signed CB Mike Mickens |
| 11/03/09 | Tampa Bay Buccaneers | Cut CB Marcus McCauley |
| 11/03/09 | New England Patriots | Practice squad addition TE Rob Myers |
| 11/03/09 | New England Patriots | Practice squad deletion TE Robert Agnone |
| 11/03/09 | Arizona Cardinals | Practice squad deletion DT Keilen Dykes |
