| Date | Player | Pos | Injury | Status | Comment |
|---|---|---|---|---|---|
| 11/16/09 | Cedric Benson | RB | hip | Day-to-Day | Expected return 11/29/09 |
| 11/13/09 | Roy Williams | S | forearm | IR | Expected return 09/12/10 |
| 11/09/09 | Chris Henry | WR | forearm | IR | Expected return 09/12/10 |
| 11/08/09 | Chris Henry | WR | forearm | Day-to-Day | Expected return 09/12/10 |
| 10/19/09 | Antwan Odom | DE | torn right Achilles tendon | IR | Expected return 09/12/10 |
| 09/05/09 | Antonio Chatman | WR | Ankle | IR | Expected return 09/12/10 |
| 08/31/09 | Matt Sherry | TE | shoulder | IR | Expected return 09/12/10 |
| 08/31/09 | Ben Utecht | TE | severe concussion | IR | Expected return 09/12/10 |
| 08/20/09 | Dan Santucci | C | foot | IR | Expected return 09/05/10 |
| 08/05/09 | Reggie Kelly | TE | ruptured left Achilles tendon | IR | Expected return 09/12/10 |
| Date | Player | Pos | Transaction |
|---|---|---|---|
| 11/24/09 | Orien Harris | DT | Signed |
| 11/24/09 | Scott Kooistra | T | Cut |
| 11/24/09 | Antonio Smith | CB | Practice squad addition |
| 11/17/09 | Ben Utecht | TE | Taken off IR severe concussion |
| 11/17/09 | Antonio Chatman | WR | Taken off IR ankle |
| 11/17/09 | Antonio Chatman | WR | Cut |
| 11/17/09 | Ben Utecht | TE | Cut |
| 11/17/09 | Brannon Condren | S | Practice squad addition |
| 11/17/09 | Larry Johnson | RB | Signed |
| 11/17/09 | Orien Harris | DT | Cut |
| 11/13/09 | Roy Williams | S | Placed on IR forearm |
| 11/13/09 | Maurice Purify | WR | Activated from the Practice Squad |
| 11/10/09 | Gerald Cadogan | T | Practice squad deletion |
| 11/10/09 | Freddie Brown | WR | Practice squad addition |
| 11/09/09 | Scott Kooistra | T | Signed |
| 11/09/09 | Chris Henry | WR | Placed on IR forearm |
| 11/03/09 | Scott Kooistra | T | Cut |
| 11/03/09 | Fui Vakapuna | RB | Signed |
| 11/03/09 | Gerald Cadogan | T | Practice squad addition |