| Player | Team | Fum | Lst | Att | Yds | Avg | Ypg | Long | TD |
|---|---|---|---|---|---|---|---|---|---|
| Chris Johnson | TEN | 1 | 1 | 199 | 1242 | 6.2 | 124.2 | 91 | 8 |
| Steven Jackson | STL | 2 | 2 | 215 | 1031 | 4.8 | 103.1 | 58 | 3 |
| Adrian Peterson | MIN | 4 | 4 | 205 | 999 | 4.8 | 99.9 | 64 | 11 |
| DeAngelo Williams | CAR | 3 | 3 | 181 | 982 | 5.4 | 98.2 | 77 | 7 |
| Maurice Jones-Drew | JAC | 1 | 1 | 194 | 926 | 4.7 | 92.6 | 80 | 13 |
| Thomas Jones | NYJ | 2 | 0 | 191 | 884 | 4.6 | 88.4 | 71 | 8 |
| Cedric Benson | CIN | 1 | 0 | 205 | 859 | 4.1 | 95.4 | 28 | 6 |
| Michael Turner | ATL | 4 | 2 | 165 | 831 | 5.0 | 92.3 | 58 | 10 |
| Ryan Grant | GB | 0 | 0 | 189 | 829 | 4.3 | 82.9 | 37 | 5 |
| Ray Rice | BAL | 0 | 0 | 148 | 733 | 4.9 | 73.3 | 50 | 6 |
| Rashard Mendenhall | PIT | 2 | 2 | 134 | 689 | 5.1 | 68.9 | 39 | 4 |
| Ricky Williams | MIA | 1 | 0 | 127 | 677 | 5.3 | 67.7 | 68 | 8 |
| Brandon Jacobs | NYG | 0 | 0 | 163 | 656 | 4.0 | 65.6 | 31 | 3 |
| Ronnie Brown | MIA | 1 | 1 | 147 | 648 | 4.4 | 72.0 | 45 | 8 |
| Frank Gore | SF | 2 | 0 | 112 | 610 | 5.4 | 76.3 | 80 | 6 |
| Knowshon Moreno | DEN | 2 | 2 | 142 | 600 | 4.2 | 60.0 | 36 | 2 |
| Pierre Thomas | NO | 1 | 1 | 105 | 584 | 5.5 | 64.9 | 34 | 5 |
| Marion Barber | DAL | 1 | 1 | 123 | 572 | 4.6 | 63.6 | 35 | 4 |
| Kevin Smith | DET | 3 | 2 | 162 | 560 | 3.4 | 56.0 | 31 | 3 |
| Ahmad Bradshaw | NYG | 2 | 1 | 115 | 549 | 4.7 | 54.9 | 38 | 4 |
| Fred Jackson | BUF | 1 | 1 | 128 | 528 | 4.1 | 52.8 | 43 | 0 |
| Matt Forte | CHI | 2 | 1 | 157 | 516 | 3.2 | 51.6 | 61 | 3 |
| Joseph Addai | IND | 1 | 1 | 145 | 514 | 3.5 | 51.4 | 21 | 7 |
| Mike Bell | NO | 2 | 2 | 115 | 514 | 4.4 | 64.3 | 35 | 4 |
| Jonathan Stewart | CAR | 3 | 2 | 110 | 509 | 4.6 | 50.9 | 45 | 6 |
| Clinton Portis | WAS | 1 | 1 | 124 | 494 | 3.9 | 61.8 | 78 | 1 |
| Beanie Wells | ARI | 3 | 1 | 100 | 469 | 4.6 | 46.9 | 29 | 4 |
| Jamal Lewis | CLE | 0 | 0 | 132 | 460 | 3.4 | 57.5 | 18 | 0 |
| LaDainian Tomlinson | SD | 0 | 0 | 135 | 458 | 3.3 | 57.3 | 36 | 6 |
| Laurence Maroney | NE | 2 | 2 | 116 | 455 | 3.9 | 45.5 | 45 | 6 |
| LeSean McCoy | PHI | 2 | 1 | 106 | 452 | 4.2 | 45.2 | 66 | 3 |
| Carnell Williams | TB | 0 | 0 | 117 | 450 | 3.8 | 45.0 | 35 | 3 |
| Tim Hightower | ARI | 3 | 2 | 102 | 430 | 4.2 | 43.0 | 50 | 5 |
| Correll Buckhalter | DEN | 3 | 2 | 73 | 399 | 5.4 | 44.3 | 45 | 1 |
| Julius Jones | SEA | 0 | 0 | 107 | 392 | 3.6 | 43.6 | 62 | 2 |
| Larry Johnson | CIN | 2 | 1 | 134 | 382 | 2.8 | 47.8 | 19 | 0 |
| Steve Slaton | HOU | 5 | 3 | 121 | 380 | 3.1 | 38.0 | 32 | 3 |
| Michael Bush | OAK | 1 | 1 | 81 | 377 | 4.6 | 37.7 | 60 | 2 |
| Felix Jones | DAL | 1 | 1 | 54 | 353 | 6.5 | 44.1 | 56 | 1 |
| Justin Fargas | OAK | 0 | 0 | 90 | 336 | 3.7 | 42.0 | 35 | 2 |
| Leon Washington | NYJ | 1 | 1 | 72 | 331 | 4.6 | 47.3 | 33 | 0 |
| Jamaal Charles | KC | 0 | 0 | 64 | 313 | 4.8 | 34.8 | 44 | 1 |
| Reggie Bush | NO | 1 | 1 | 55 | 277 | 5.0 | 30.8 | 55 | 5 |
| Marshawn Lynch | BUF | 3 | 1 | 87 | 272 | 3.1 | 38.9 | 14 | 1 |
| Tashard Choice | DAL | 0 | 0 | 55 | 263 | 4.7 | 26.3 | 36 | 3 |
| Willis McGahee | BAL | 1 | 1 | 66 | 261 | 3.9 | 26.1 | 34 | 5 |
| Jason Snelling | ATL | 0 | 0 | 62 | 259 | 4.1 | 32.4 | 31 | 3 |
| Justin Forsett | SEA | 2 | 1 | 45 | 255 | 5.6 | 25.5 | 24 | 2 |
| Jerome Harrison | CLE | 1 | 1 | 69 | 254 | 3.6 | 31.8 | 21 | 0 |
| Derrick Ward | TB | 0 | 0 | 66 | 243 | 3.6 | 27.0 | 28 | 1 |
