| Player | Team | Rat | Att | Com | Com% | Yds | Avg | Long | Tds | TD% | Int | Int% | Sck | S/Yds |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Brett Favre | MIN | 112.1 | 310 | 216 | 69.7 | 2482 | 8.0 | 63 | 21 | 6.8 | 3 | 1.0 | 21 | 150 |
| Drew Brees | NO | 105.8 | 320 | 218 | 68.1 | 2746 | 8.5 | 66 | 22 | 6.9 | 9 | 2.8 | 13 | 84 |
| Peyton Manning | IND | 102.7 | 388 | 271 | 69.8 | 3171 | 8.1 | 80 | 21 | 5.4 | 9 | 2.3 | 8 | 58 |
| Aaron Rodgers | GB | 102.6 | 341 | 221 | 64.8 | 2788 | 8.1 | 74 | 19 | 5.6 | 5 | 1.5 | 43 | 254 |
| Tom Brady | NE | 100.4 | 393 | 261 | 66.4 | 3049 | 7.7 | 71 | 20 | 5.1 | 6 | 1.5 | 14 | 78 |
| Matt Schaub | HOU | 98.9 | 365 | 245 | 67.1 | 2958 | 8.1 | 72 | 19 | 5.2 | 9 | 2.5 | 19 | 118 |
| Philip Rivers | SD | 98.7 | 321 | 203 | 63.2 | 2621 | 8.1 | 81 | 17 | 5.3 | 6 | 1.9 | 20 | 138 |
| Ben Roethlisberger | PIT | 98.6 | 344 | 237 | 68.9 | 2867 | 8.3 | 52 | 17 | 4.9 | 10 | 2.9 | 30 | 209 |
| Donovan McNabb | PHI | 95.9 | 250 | 154 | 61.6 | 1929 | 7.7 | 58 | 14 | 5.6 | 5 | 2.0 | 22 | 178 |
| Kurt Warner | ARI | 94.4 | 372 | 251 | 67.5 | 2718 | 7.3 | 44 | 20 | 5.4 | 11 | 3.0 | 16 | 128 |
| Eli Manning | NYG | 92.2 | 314 | 190 | 60.5 | 2454 | 7.8 | 62 | 18 | 5.7 | 9 | 2.9 | 14 | 98 |
| Tony Romo | DAL | 91.5 | 330 | 198 | 60.0 | 2624 | 7.9 | 80 | 15 | 4.5 | 7 | 2.1 | 23 | 128 |
| Joe Flacco | BAL | 89.1 | 335 | 219 | 65.4 | 2455 | 7.3 | 72 | 12 | 3.6 | 8 | 2.4 | 18 | 120 |
| Kyle Orton | DEN | 87.8 | 316 | 196 | 62.0 | 2202 | 6.9 | 87 | 11 | 3.5 | 5 | 1.6 | 14 | 80 |
| Carson Palmer | CIN | 87.2 | 312 | 192 | 61.5 | 2217 | 7.1 | 73 | 14 | 4.5 | 8 | 2.6 | 17 | 139 |
| Jason Campbell | WAS | 86.1 | 291 | 192 | 66.0 | 2126 | 7.3 | 59 | 10 | 3.4 | 9 | 3.1 | 29 | 172 |
| David Garrard | JAC | 83.9 | 322 | 199 | 61.8 | 2303 | 7.1 | 61 | 8 | 2.5 | 6 | 1.9 | 22 | 121 |
| Matt Hasselbeck | SEA | 82.3 | 281 | 169 | 60.1 | 1853 | 6.5 | 53 | 11 | 3.9 | 7 | 2.5 | 16 | 106 |
| Alex Smith | SF | 81.5 | 155 | 95 | 61.3 | 1035 | 6.6 | 40 | 9 | 5.8 | 7 | 4.5 | 13 | 76 |
| Matt Ryan | ATL | 80.0 | 344 | 204 | 59.3 | 2276 | 6.6 | 90 | 16 | 4.7 | 12 | 3.5 | 14 | 64 |
| Shaun Hill | SF | 79.6 | 155 | 87 | 56.1 | 943 | 6.0 | 61 | 5 | 3.2 | 2 | 1.3 | 18 | 107 |
| Matt Cassel | KC | 77.9 | 289 | 159 | 55.0 | 1720 | 5.9 | 61 | 12 | 4.2 | 6 | 2.1 | 34 | 195 |
| Chad Henne | MIA | 77.7 | 218 | 127 | 58.3 | 1337 | 6.1 | 67 | 6 | 2.8 | 4 | 1.8 | 16 | 119 |
| Jay Cutler | CHI | 74.5 | 381 | 235 | 61.7 | 2524 | 6.6 | 68 | 15 | 3.9 | 18 | 4.7 | 20 | 127 |
| Trent Edwards | BUF | 74.1 | 181 | 109 | 60.2 | 1170 | 6.4 | 46 | 6 | 3.3 | 7 | 3.9 | 21 | 120 |
| Marc Bulger | STL | 70.7 | 247 | 140 | 56.7 | 1469 | 5.9 | 50 | 5 | 2.0 | 6 | 2.4 | 14 | 85 |
| Brady Quinn | CLE | 70.4 | 141 | 80 | 56.7 | 812 | 5.7 | 59 | 5 | 3.5 | 5 | 3.5 | 15 | 77 |
| Matthew Stafford | DET | 66.9 | 308 | 170 | 55.2 | 1911 | 6.2 | 75 | 11 | 3.6 | 14 | 4.5 | 18 | 128 |
| Jake Delhomme | CAR | 66.0 | 287 | 164 | 57.1 | 1885 | 6.5 | 52 | 8 | 2.8 | 14 | 4.9 | 20 | 161 |
| Kerry Collins | TEN | 62.0 | 197 | 108 | 54.8 | 1071 | 5.4 | 69 | 5 | 2.5 | 8 | 4.1 | 6 | 37 |
| Mark Sanchez | NYJ | 61.1 | 265 | 138 | 52.1 | 1791 | 6.7 | 53 | 10 | 3.8 | 16 | 6.0 | 17 | 141 |
| JaMarcus Russell | OAK | 47.7 | 205 | 96 | 46.8 | 1064 | 5.1 | 86 | 2 | 1.0 | 9 | 4.4 | 24 | 142 |
| Derek Anderson | CLE | 36.2 | 154 | 66 | 42.9 | 681 | 4.4 | 43 | 2 | 1.3 | 9 | 5.8 | 9 | 72 |
